Probenecid W/Colchicine

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Do not share this medication with others.

Being overweight, drinking too much alcohol, and eating certain foods may worsen gout symptoms. Limit alcohol and ask your doctor, pharmacist, or dietitian about avoiding foods high in purines that may worsen gout (such as anchovies, bacon, beer, sardines, organ meats including liver/kidneys).

Lab and/or medical tests (such as blood tests, liver/kidney function) may be done while you are taking this medication. Keep all medical and lab appointments. Consult your doctor for more details.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

Nausea, cramping, diarrhea, loss of appetite, dizziness, hair loss, headache, vomiting, and frequent urination may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: nausea/vomiting that doesn't stop, muscle weakness or pain, numbness/tingling in your fingers or toes, pale or gray color of the lips/tongue/palms of hands, severe diarrhea, severe stomach/abdominal pain, signs of infection (such as sore throat that doesn't go away, fever), unusual bleeding/bruising, unusual weakness/tiredness, dark urine, yellowing eyes/skin, fast heartbeat, shortness of breath, signs of kidney problems (such as change in the amount of urine).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at MedWatch: The FDA Safety Information and Adverse Event Reporting Program.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

See also How to Use and Precautions sections.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: drugs that can increase uric acid in the blood (such as pyrazinamide).

This medication can slow down the removal of other medications from your body, which may affect how they work or increase the risk of serious side effects. Examples include baricitinib, ceftazidime/avibactam, fosfomycin, ketoprofen, ketorolac, methotrexate, pralatrexate, among others.

Other medications can affect the removal of this medication from your body, which may affect how this drug works or increase the risk of serious side effects. Examples include atazanavir, certain azole antifungals (such as itraconazole, ketoconazole), diltiazem, macrolide antibiotics (such as clarithromycin, erythromycin), ritonavir, telithromycin, verapamil, among others.

This medication may rarely cause a certain serious (even fatal) muscle damage (rhabdomyolysis). This muscle damage releases substances that can lead to serious kidney problems. The risk may be increased if other drugs that may also cause rhabdomyolysis are taken along with this drug. Some affected drugs include: digoxin, gemfibrozil, pravastatin, simvastatin, among others.

This medication may interfere with certain lab tests (such as urine glucose tests), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.

Take this medication by mouth as directed by your doctor, usually twice daily with a full glass of water (8 ounces/240 milliliters). If stomach upset occurs, this medication may be taken with food or antacid. To prevent kidney stones while taking this drug, drink plenty of fluids throughout the day unless your doctor directs you otherwise. Taking products such as sodium bicarbonate and avoiding large amounts of vitamin C can also help reduce your risk for kidney stones. Ask your doctor for more details.

The dosage is based on your medical condition and response to treatment. To reduce your risk for serious side effects, do not increase your dose, take it more often, or take it for a longer time than directed by your doctor. Your doctor may start you on a lower dose and adjust your dose during treatment with this medication.

After starting this medication, you may have an increase in the number of gout attacks while your body gets rid of extra uric acid. This may last for several months until the uric acid in your blood is lowered. Do not stop taking this drug if you have a sudden gout attack. Keep taking it along with the medications (such as colchicine, ibuprofen, indomethacin) prescribed by your doctor for gout pain.

Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.

Tell your doctor if your condition does not get better or if it gets worse.

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call 1-800-222-1222. Canada residents can call 1-844-764-7669. Symptoms of overdose may include: severe vomiting, loss of consciousness, seizures.